The Great Uzbek Highway is a highway in Uzbekistan on the site of an ancient road that once led to India. This road was one of the branches of the Great Way, which at one time connected India with Bactria, Sogda, Parthia, Assyria, Byzantium and Egypt. Along this path in the 4th century BC. e. passed with his army after the victory over the last Persian ruler Darius III Alexander the Great, and in the XIII century Marco Polo traveled to China on it.
Today this road connects Tashkent and Termez, 708 km long. It was built in 1939-1940. The road passes through the regional centers of Uzbekistan: Gulistan, Jizzakh, Samarkand, Karshi. In addition, the Great Uzbek Highway is a section of the Alma-Ata-Bishkek-Tashkent-Termez highway.